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Study reveals increased risk of immune abnormalities in children of women with HIV – News-Medical.Net

Researchers have found that children of women with HIV infection have an increased risk of immune abnormalities following exposure to maternal HIV viremia, immune dysfunction, and co-infections during pregnancy. 

The study, led by Dr Ceri Evans while at Queen Mary University of London, compared clinical outcomes between infants who were HIV-exposed and HIV-unexposed in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe. Despite high coverage of maternal antiretroviral therapy (ART) and uptake of exclusive breastfeeding, mortality in infants exposed to HIV was 41% higher than in infants not exposed to HIV. Infants who survived and remained HIV-free had impaired growth and development. 

Analysis of blood samples from both mothers and children in the trial showed evidence of several biological pathways that contributed to the increased mortality seen in this cohort of infants. Systemic inflammation among women with HIV, as measured by C-reactive protein (CRP), was strongly associated with infant mortality, suggesting that interventions targeting maternal inflammation and its causes during pregnancy might reduce infant mortality. Researchers also found that the immune development of HIV-exposed babies – and especially boys – was different to those who had not been exposed to HIV, making it less effective in dealing with future infections. Infection with cytomegalovirus (CMV), which is a co-factor in HIV disease progression, was also found to be independently associated with infant mortality, as well as impacting on the development of the child’s immune system. 

Collectively, these findings show how the skewed immune milieu of women with HIV in pregnancy – characterized by inflammation, immune dysfunction, and co-infections – shapes immune development in their offspring. Inflammation, as indicated by CRP, is inexpensive and simple to measure, offering the immediate opportunity for antenatal point-of-care testing to be used to identify those most at risk of infant mortality, with more support provided for high-risk pregnancies. CMV co-infection, which is common in sub-Saharan Africa, may offer a new intervention target to improve outcomes in this vulnerable population of children.”

Dr. Ceri Evans, NIHR Clinical Lecturer in Paediatric Infectious Diseases now at the University of Liverpool

Dr Marlène Bras, HIV Programmes and Advocacy Director at IAS – the International AIDS Society – said: ‘The IAS Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) awarded Dr Evans a grant in 2019 for his project, “The impact of improved water, sanitation and hygiene (WASH) on cytomegalovirus co-infection in HIV-affected mothers and children in rural Zimbabwe”. Dr Evans is a prime example of the importance of programs such as CIPHER in supporting early-stage investigators and fostering innovative solutions for an integrated HIV response for infants, children, adolescents and young people living with and affected by HIV. We congratulate Dr Evans on his successes and look forward to working with him in the future.’ 

Journal reference:

Evans, C., et al. (2024). Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants. Nature Communications. doi.org/10.1038/s41467-023-44166-2.

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KoSamuriwo to celebrate Workers’ Day with live performance by Ramsey Kay


Sipepisiwe Moyo, [email protected]

Tomorrow, KoSamuriwo, a favoured local hangout located at Chigumira shops in the Old Luveve suburb of Bulawayo, will host a special celebration in honour of Workers’ Day.

The evening’s entertainment will kick off at 6pm with a performance by renowned jazz artiste Ramsey Kay and the Big Ray band. Additionally, various DJs will take turns on the decks throughout the event, adding to the festive atmosphere.

Known city-wide for its affordable beer prices and tight security, KoSamuriwo has quickly become a go-to spot for many locals. Since its grand opening on New Year’s Eve last year, the venue has successfully hosted a variety of events, earning a reputation as a vibrant and safe place for relaxation and entertainment.

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2 astronaut taxis: Why NASA wants both Boeing’s Starliner and SpaceX’s Dragon – Space.com

HOUSTON — The United States’ second private crew-carrying spacecraft is finally ready to bear astronauts.

NASA and Boeing teams recently cleared for liftoff the Crew Flight Test (CFT) of Boeing’s Starliner, which is set to launch on May 6. Starliner will be the second spacecraft funded by the agency’s commercial crew program to carry astronauts, following SpaceX‘s Crew Dragon, which made its crewed debut in May 2020.

“We are really excited to have this second transportation system up and available to us,” Steve Stich, program manager for NASA’s Commercial Crew Program, said in a press conference here at the agency’s Johnson Space Center on March 22.

Stich emphasized that the program had wanted, all along, two very different spacecraft with different procedures and teams to support them, to have a backup in case one ship is sidelined due to a safety or other issue. “We’ve seen in the past the importance, I think, of having this dissimilar redundancy, [because] it’s always tough to fly into space,” he said.

Related: 1st Boeing Starliner astronauts are ready to launch to the ISS for NASA (exclusive)

CFT will bear two NASA veteran astronauts and former Navy test pilots into space, Butch Wilmore and Suni Williams. They will shake down the spacecraft during a “developmental” mission, meaning that a few changes may happen to procedures, teamwork or the spacecraft following “lessons learned” from this flight. Assuming all goes well, Starliner will then be certified for six-month missions to the ISS next year.

SpaceX and Boeing both received contracts from NASA in 2014 to ferry astronauts to and from the International Space Station (ISS), with SpaceX receiving a contract valued at $2.6 billion and Boeing one at $4.2 billion. SpaceX began running its operational missions in 2020 and has sent 11 such crews to the ISS so far (eight for NASA and three for Axiom Space, a private company that organizes short-term stays on the complex.)

Starliner has flown two uncrewed missions in space. The capsule’s astronaut debut has been delayed multiple times due to technical issues, most of them experienced during its first test flight in 2019, which failed to meet up with the ISS as planned. Starliner’s second test flight to the orbiting lab, in May 2022, met all of its major objectives. Further delays arose more recently, due to issues with Starliner’s parachute system and the fact that much of its wiring was wrapped in flammable tape.

During press activities here in Houston, Boeing, NASA and the astronauts emphasized repeatedly that those earlier problems have all been addressed. Should CFT go as planned and all schedules hold, Boeing will launched the operational crewed mission Starliner-1 to the ISS for a six-month stay in early 2025, with more flights to follow.

Related: Boeing begins fueling Starliner capsule ahead of 1st astronaut launch

SpaceX’s Crew Dragon Endeavour (bottom center) and a visiting uncrewed cargo Dragon supply ship (foreground), are seen docked at the International Space Station’s Harmony module in September 2021. (Image credit: NASA)

Despite the Starliner delays, the U.S. is about to have two private crew-carrying spaceraft at its disposal, which will provide ISS backup in many forms. Dana Weigel, then deputy program manager for the ISS, pointed out in the March 22 press conference that one of the program’s goals is to keep the station continuously crewed. The station’s life support systems assume “constant throughput” from humans, among other items, and the astronauts do preventative maintenance on the complex as well.

“When we talk about having multiple providers, [that’s] why it’s so important for us to have that continual capability,” added Weigel, who was promoted to program manager for the ISS on April 7.

Boeing’s Starliner makes its first uncrewed approach to the International Space Station during Orbital Flight Test-2 on May 21, 2022. (Image credit: NASA)

Incidentally, these are not the only crewed spacecraft flying to and from the ISS; Russia’s Soyuz spacecraft has been doing so ever since the complex joined its first two modules in 1998. Soyuz and NASA’s space shuttle used to trade off astronaut missions back in the day; the shuttle retired in 2011.

Soyuz had to go it alone for nearly a decade after the space shuttle retired, but that’s far from ideal; NASA wants backup for safety and policy reasons. For example, a Soyuz spacecraft in 2022 sprung a coolant leak that essentially forced Russia to ship a new Soyuz vehicle to space as rapidly as possible for the three astronauts needing a ride home.

In the meantime, mission managers squeezed an extra seat on board a docked SpaceX Dragon, in case there was trouble on the ISS that forced evacuation,. (Russian tests suggested the remaining two astronauts manifested on Soyuz could safely fly home on the coolant-less spacecraft.) That backup was not necessary, but all the additional spacecraft changes forced the Soyuz astronauts to double their stay to a year, while awaiting their relief crew.

Related: How many astronauts can fly on a SpaceX Crew Dragon capsule?

Coolant leaking from Russia’s Soyuz crew capsule docked to the International Space Station in December 2022. (Image credit: NASA)

Weigel specifically pointed to this leak situation as “a great example where … we were able to leverage contingency capability, in this case with Crew Dragon.” 

While SpaceX is highly reliable, backups are always appreciated; Weigel noted that all Dragons fly on a single rocket, the Falcon 9 or F9, which is also used to launch SpaceX Starlink satellites and other missions. 

“If there was a problem with F9, for example — and we had to stand down for a while to understand the problem — if we had another vehicle, we could continue flying,” she said.

NASA Crew Flight Test astronauts Butch Wilmore and Suni Williams in front of a T-38 trainer at Ellington Field, nearby NASA’s Johnson Space Center in Houston. (Image credit: NASA/Robert Markowitz)

This all assumes, of course, that Starliner passes all of its testing. Mark Nappi, vice president and program manager of Boeing’s commercial crew program, outlined for reporters several key milestones the company is tracking.

Boeing wants to make sure the CFT astronauts are comfortable and can work with all the equipment at all phases of the mission, which means key systems like life support need to work properly. Thruster performance will be evaluated during dynamic events — like ISS approach, rendezvous and docking — along with the manual and auto navigation systems. Starliner will also need to perform well during its approximate week at the ISS, when it goes into “quiescent” mode to save on energy.

“Then we’ll undock,” Nappi continued. “We’ll confirm our manual piloting system; we’ll be able to go into the backup mode and let Butch and Suni use the hand controllers to make sure it acts as expected.” From there, he continued, Starliner will be evaluated on its performance during reentry and landing, including aspects such as its heat shield, parachute and human recovery operations.  

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Stich pointed to another benefit of commercial crew: allowing each of the contractors (Boeing and SpaceX) to choose how they want to operate as long as all certification and safety requirements are met. 

SpaceX, for example, has all of its mission control operations at its headquarters in Hawthorne, California. Boeing chose to split its teams between JSC and a mission control center in Florida. Because Boeing is co-located with NASA employees here at JSC, Stich emphasized, there is an advantage.

“It’s allowed NASA to keep some of those critical flight operations skills, training the crews and then operating the vehicle for launch and landing phases in those critical phases of flight,” Stich said. That experience will be useful for cross-training, he said, as NASA prepares to certify its Lockheed Martin-led Orion spacecraft for moon missions as soon as 2025, with Artemis 2.  

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First year of DESI results unveil new clues about dark energy – The Ohio State University News

Researchers at The Ohio State University played a major role in analyzing the first year of data from the Dark Energy Spectroscopic Instrument’s survey into the history of the universe.

With 5,000 tiny robots in a mountaintop telescope, the Dark Energy Spectroscopic Instrument (DESI) collects and measures light from faraway space objects, granting scientists the ability to peer 11 billion years into the past. Studying how the cosmos evolved is important to understand how it began and might end, and opens up further questions about dark energy, an unknown ingredient causing our universe to expand faster and faster. 

To study dark energy’s effects over the last 11 billion years, DESI recently created the largest 3D map of the universe ever constructed, marking the first time that scientists have measured the expansion history of the universe in that early period. Such precise results have revealed unprecedented new hints about how the young universe might have evolved. Several members of the Ohio State DESI Team. From left to right, Erik Zaborowski, Chun-Hao To, Paul Martini, Peter Taylor, Klaus Honscheid, Andrei Cuceu and Ashley Ross.

DESI, an international collaboration involving more than 900 scientists from over 70 institutions around the world, is managed by the Department of Energy’s Lawrence Berkeley National Laboratory and includes large contributions from its Ohio State members. Led by physics professor Klaus Honscheid and astronomy and physics professor Paul Martini, the group now includes professors, research scientists, and graduate and undergraduate students from across the university.

Two Ohio State members, Andrei Cuceu, a postdoctoral fellow in astronomy and co-convener of the Lyman alpha science working group who led efforts to validate the instrument’s latest results, and Ashley Ross, a research scientist at the university’s Center for Cosmology and AstroParticle Physics and co-lead of the group that prepared DESI’s map for interpretation and accounted for changes in the instrument’s performance, were integral to the recent DESI discoveries. 

“DESI looks at a wide range of times across the history of the universe and our work looked at some of those most distant measurements,” said Cuceu. “We did this by measuring a feature called baryon acoustic oscillations (BAO), minute ripple patterns that the universe provides that indicate the distribution of matter as it evolves.”

Large-scale surveys have used BAO measurements as cosmic rulers to map universe expansion in great detail, as researchers can get a better grasp of how dark energy may have stretched the universe at certain points and distances in time by comparing how they ripple through space. In a study led by Cuceu, one team used them to confirm the accuracy of 150 artificial datasets made to mimic DESI’s first data release, eventually concluding that the instrument’s findings were accurate throughout many different cosmological constraints. 

“We threw it at many different types of models and decisions across the analysis process, and it always seemed to generate roughly the same end result,” said Cuceu. Their findings are monumental because they show that DESI’s results provide tantalizing suggestions that call into question both typical models of cosmology and scientists’ current ideas about how physics works, said Ross.

One of the experiment’s goals is to essentially explore the nature of dark energy and if it changes over time,” he said. “These first DESI results offer a hint that it might not be a cosmological constant.”

 This artist’s rendering shows light from quasars passing through intergalactic clouds of hydrogen gas. Researchers can analyze the light to learn about distant cosmic structure. Credit: NOIRLab/NSF/AURA/P. Marenfeld and DESI collaborationDESI’s first research findings are presented throughout multiple papers, which can be found on the instrument’s data documentation site.

Beyond dark energy, DESI has also been used to study many other cosmological mysteries important for physics, such as the mass of important particles called neutrinos and how individual galaxies develop over time. Martini, who was the instrument scientist for DESI during its construction and commissioning, said that what makes DESI’s results so groundbreaking is the depth of the instrument’s analysis. 

“The improvement that we have managed to achieve is really driven not just by the fact that we have 10 times as much data as previous projects, but also that we took time to really understand the steps and potential sources of uncertainty much better,” Martini said.

As light from a distant quasar passes through gas in space, certain wavelengths of light are absorbed. Plotting the absorption lines reveals the “Lyman-alpha forest” (emphasized here in brown and green) and provides information about the distant clouds of gas between us and the quasar.  Credit: David Kirkby/DESI collaboration

This analysis covers data collected from 2021 to 2022, and DESI has been collecting new data ever since, meaning there are now three years of promising new data for scientists to comb through. 

“For now, we’re experimenting in a new era of cosmology,” said Cuceu. 

Toward the end of the decade, the data DESI continues to collect will also be used to complement next-generation sky surveys, such as the Vera C. Rubin Observatory and Nancy Grace Roman Space Telescope. As those instruments collect more precise data and scientists get to work decoding their results, many are confident that even more exciting pieces of the universe’s ever-changing cosmic puzzle will be revealed. 

“It is a really exciting result that could indicate a significant change in our understanding of the universe, and the fact that we see these hints about dark energy gives us fuel to keep going,” said Honscheid, who is the current DESI instrument scientist and instrument operations lead. “The future looks extremely bright for DESI and other long-term experiments like this one.”

​DESI is supported by the DOE Office of Science and by the National Energy Research Scientific Computing Center, a DOE Office of Science user facility. Additional support for DESI is provided by the U.S. National Science Foundation, the Science and Technology Facilities Council of the United Kingdom, the Gordon and Betty Moore Foundation, the Heising-Simons Foundation, the French Alternative Energies and Atomic Energy Commission (CEA), the National Council of Science and Technology of Mexico, the Ministry of Science and Innovation of Spain, and by the DESI member institutions. 

The DESI collaboration is honored to be permitted to conduct research on Iolkam Du’ag (Kitt Peak), a mountain with particular significance to Tohono O’odham Nation.

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